Research Library
Daddy reads a LOT of science papers! He stays up late so he can understand them. This is where he explains them in simple words — so your family's doctors can have better conversations with you.
📚 How to use this
Each study is summarized in everyday language with its evidence rating. These are meant to help you talk to your doctors — not replace them. The ratings reflect study quality, not our personal endorsement.
Cerebral Folate Deficiency & FRAAs
Cerebral Folate Receptor Autoantibodies in ASD Strong
Frye RE, Sequeira JM, Quadros EV, et al. — Molecular Psychiatry, 2013
In plain language: Found that about 71% of children with ASD tested positive for FRAAs — establishing CFD as one of the most prevalent treatable biomedical findings in autism.
Folinic Acid Improves Verbal Communication in Children with Autism Strong
Frye RE, Slattery J, Delhey L, et al. — Molecular Psychiatry, 2018
In plain language: A randomized, double-blind trial of leucovorin in 48 children with ASD. Those who received treatment showed significant improvements in verbal communication, especially those positive for FRAAs.
Autoantibodies to Folate Receptors in Cerebral Folate Deficiency Syndrome Strong
Ramaekers VT, Blau N, Sequeira JM, et al. — New England Journal of Medicine, 2005
In plain language: The foundational paper that identified FRAAs as a cause of cerebral folate deficiency and showed that leucovorin treatment could normalize brain folate levels.
Dietary Interventions
GFCF Dietary Intervention for Autism Spectrum Conditions Moderate
Whiteley P, Haracopos D, Knivsberg AM, et al. — Frontiers in Human Neuroscience, 2010
In plain language: A two-year randomized trial of the GFCF diet in children with ASD found significant improvements in attention, social interaction, and communication in the diet group.
Vitamin D
Randomized Controlled Trial of Vitamin D in Children with ASD Moderate
Saad K, Abdel-Rahman AA, Elserogy YM, et al. — Journal of Child Psychology and Psychiatry, 2018
In plain language: RCT of vitamin D3 in 109 children with ASD. The treatment group showed significant improvements across multiple ASD rating scales compared to placebo.
🚀 More coming
We're adding studies on omega-3s, probiotics, oxalate metabolism, and mitochondrial support. If there's a specific study you'd like covered, let us know.